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ChimieMétaux & Minéraux

NEW INNOVATIVE SYNTHESES OF BORON PHOSPHIDE

Boron phosphides (BP and B12P2) are characterized by high hardness (Hv > 30GPa), low density, high thermal conductivity and a high thermal and chemical stability (up to 1500K in air). They can be used in many industries including automotive, mechanical engineering and mining as cutting tools, construction part or wearresistant coatings. However, these promising two materials are not yet industrially used because of the lack of mass production method. Currently polycrystalline boron phosphides powders are traditionally synthesized by slow processes requiring toxic and aggressive reagents and high energy. Two new approaches of producing boron phosphide powders have been discovered and patented. These 2 processes, SHS (Self-Propagating High-Temperature Synthesis) and mecanochemistry, enable to synthesize either BP or B12P2 nanopowders with high purity (>97%), from readily available and non-toxic reagents. These new fast, safe, reproducible and scalable syntheses now enable the development of a wide use of boron phosphides.

Competitive advantages :

  • Rapid synthesis
  • Nontoxic and available reagents
  • High reproducibility
  • High purity of the synthetized product
  • Potential for easy industrial implementation and low cost synthesis

Applications :

  • Wear parts
  • Wear-resistant coating
  • Cutting tools

Keywords : Boron phosphide, BP, B12P2, Synthesis, SHS, Mecanochemistry, High hardness, Hard material

PhysiqueEnergie & Systèmes électriquesEnvironnement & Construction

NON HOMOGENOUS BLADES

The innovation tackles a method for designing wind turbine blades. The aim of the technology is to adapt the different materials used for the blades, especially taking into account their Young modulus and volumic mass so as to extend the optimal working regime of the turbine blade. In addition to theoretical calculations, first experiments have shown an increase of around 35% in wind conversion rates, and the ability to be functional in a wider variety of wind speeds.

Competitive advantages :

  • Large operative range
  • Low energy for manufacturing
  • Easy to set-up

Applications : 

  • Wind Power
  • Hydrokinetic power

Keywords : Blades, Wind, Hydrokinetic, Power windmill, Flexible, Conversion rate

Sciences pour l'ingénieurEcologie / EnvironnementChimie, Matériaux & Produits alimentairesEnvironnement & Construction

SOLID-SOLID PHASE CHANGE MATERIAL

PCM improve thermal performances of buildings by delaying temperature increase and decrease and by mitigating the temperature peaks. Most PCM available for building material purposes are based on state change implying solid and liquid transitions which present major issues for buildings such as leakage risks. Our technology is based on a solid-solid phase change material that avoids any leakage risks. The temperature of phase change can be tuned between 20°C to 35°C according to the chosen target (higher transition temperatures are currently under development). Latent heat ranges from 80 to 116 J/g depending on the phase change temperature. The PCM presents a Shore hardness which allows its grinding up to grain size lower than 50 μm. The grain size of the PCM can be controlled by sieving. The environmental impact of the PCM is limited, as the synthesis process does not involve any solvent. The PCM is expected to improve the resistance to fire. The phase transition will delay the temperature rise of the building materials, and the degradation temperature of the PCM up to 450°C.

Competitive advantages :

  • Good thermal performances: up to 116 J/g
  • No liquid phase, no encapsulation requirement
  • Water resistant
  • Solvent-free synthesis
  • Limited mechanical properties degradation
  • Controlled grain size
  • Resistance to fire

Applications : 

  • Energy efficient building materials (plaster, cement...)
  • Thermal efficient packaging
  • Cooling electronic circuits

Keywords : Solid-solid Phase Change Material, Thermal energy storage, Phase shift, Energy efficiency, Thermal comfort, Sustainable building

PhysiqueSTICSTIC

ALGAAS-ON-INSULATOR PLATFORM

III-V semiconductors are a category of materials useful for optoelectronics applications, thanks to the physical properties of their crystalline structures. AlGaAs is one of them and has superior performances over silicon such as:
• No Two Photon Absorption @ 1.55 μm
• Direct laser emission
• Optical modulation at higher frequency rate.
The AlGaAs-on-Insulator plateform, which exhibits higher performances than SOI, was achieved thanks to a monolithic construction combining a high-contrast refractive-index ratio between the insulating layer and the AlGaAs waveguide. Our invention deals with the monolithic fabrication of a thick layer of AlOx (>1μm), which plays the role of optical substrate and enhances the light confinement inside an AlGaAs heterostructure on top of it. Our technology can first be used to develop Surface Plasmon Resonance (SPR) sensors based on a dielectric, instead of gold or silver, thus avoiding local heat peaks that can affect the sensitivity of the sensor. As a first proof of concept, frequency doubling has been demonstrated (see picture), with a conversion efficiency up to 5 orders of magnitude higher than the established record of second harmonic generation for plasmonic nanoantennas. Our technology could also be used to design low lasing threshold and fast modulation laser, which would lead to decrease the electric consumption of lasers used for example in datacenters.

Competitive advantages :

  • Light confinement
  • Low lasing threshold
  • High conversion rate for Second Harmonic Generation

Applications :

  • Lasers for Datacenters
  • Surface Plasmon Resonance (SPR) sensors

Keywords : Photonics, Non linear optics, Laser, AlGaAs, Insulator, III-V semiconductors, Monolithic platform

ChimieSciences pour l'ingénieurEcologie / EnvironnementNormes, institutions & comportement sociauxChimie, Matériaux & Produits alimentairesMesures & Instrumentation

ELECTRICAL CONDUCTIVITY MEASUREMENT CLAMP FOR ION EXCHANGE MEMBRANES

Existing techniques for measuring electrical conductivity of hydrophilic films, as ion exchange membranes (IEM), either work with solutions at low concentrations, or provide hard-to-reproduce measures, or require to take the membrane out of its equilibrating solution, thus inducing a bias in the measurement. Our technology is a clamp with two articulated arms that characterizes the IEM with no bias in measurement thanks to a contactless technology enabling on-site measurement with no contact resistance induced. It is compatible with a wide range of concentrations of equilibrating solutions (from 0.01 M to 1 M) and is compatible for membranes or hydrophilic films with a thickness between 50μm and 1 millimeter, making on-site measures convenient and reliable. Measure precision is 1% for solutions with a concentration inferior to 0.1 M and 3% for 1 M concentrations.

Competitive advantages :

  • Compatible with a wide range of equilibrating solutions concentrations
  • Highly accurate & reliable & reproducible measurements
  • Portable
  • On-site measures (with the membrane in electrolyte)
  • No-use of mercure
  • Wide range of concentrations
  • Non-destructive testing of supports
  • Measurement of alternating current at different frequencies, or direct current

Applications :

  • Water desalination
  • Water treatment for drinking water
  • Agribusiness (milk, fruit juices etc.)
  • Industrial wastewater

Keywords : Clamp, Electrical conductivity, Ion-exchange membranes (IEM), Hydrophilic films, NF X45-200 norm

PhysiqueSciences pour l'ingénieurEnergie & Systèmes électriques

FLEXIBLE ELECTROSTATIC KINETIC ENERGY HARVESTER

Our device converts mechanical energy into electricity, when repeatedly pressed and released by an external mechanical action. The device has a sandwich structure, with flexible or solid electrodes on the surface and with an organic electret material core (see picture). It can be embedded into an object, a cloth or be used as a “second skin”. Electric charges trapped within the device induce an electric current through a charge when a mechanical deformation is applied. The device has no resonance frequency and thus works at any mechanical frequency. Besides, the organic material is designed in such a way so that electric charges remain stable over time, leading to long standing performances. With a finger tapping activation, the first 3cmx3cm prototype reaches a peak voltage of 27 V and a power of 45.6 μW. Performances can be further largely enhanced by optimizing triboelectric effect, increasing the size of the device and/or by using it under different conditions (higher mechanical frequencies, more pressure).

Competitive advantages :

  • Flexible or solid surface
  • Works at any mechanical frequency
  • Long standing electric charge storage

Applications

Powering/improving battery lifetime for :

  • Embedded chips in smart clothes and shoes
  • “Second skin” biomedical sensors
  • Smart cards, semi-active RFID systems,
  • Strain or pressure sensors (for car wheels for example)

Keywords : Mechanical (kinetic) energy harvester, (Tribo)electret material, Triboelectricity, Electrostatic transducer

PhysiqueChimieSciences pour l'ingénieurMesures & Instrumentation

COLLOIDAL SERS SUBSTRATE

Every type of molecule has a distinct «Raman signature» that can be enhanced by special surfaces called SERS substrates, standing for “Surface Enhanced Raman Spectroscopy”. SERS techniques are useful to detect molecules at very small concentrations (pico or femtomoles per litre). The SERS substrate can either be generic or designed for special applications, such as trace detection of explosives, drugs or pollutants. Common techniques to produce SERS substrates involve lithography processes, and are thus rather costly. On top of that, measures lack of reproducibility. Our invention is based on a bottom-up colloidal synthesis, as the substrate results of the self-organization of metallic nanorods. Measures are more reproducible and reliable than Renishaw Klarite substrates. For example, first comparisons with commercial SERS show a better signal to noise ratio, with twice less variability, hence allowing a better ability to discriminate and to detect traces (see picture).

Competitive advantages :

  • High enhancement factor
  • Designed to be cheap
  • Reproductibility of measures

Applications :

  • Explosives trace detection
  • Drugs trace detection
  • Pollutants trace detection
  • Forensics : anti-counterfeiting

Keywords : Raman spectroscopy, Self-organization of nanoparticules, Trace detection, SERS : surface enhanced Raman spectroscopy

Biologie / SantéSanté

TREATING LIFE-THREATENING PURPURA FULMINANS

Purpura fulminans (PF) is an uncommon but fatal disorder characterized by rapidly progressive thrombosis with hemorrhagic infarction, disseminated intravascular coagulation and multi-organ failure, which leads to death in 30% of patients and often severe sequelae in survivors. PF is a feature of severe sepsis in response to infection by a wide range of bacteria species, among which Neisseria meningitides, Streptococcus pneumoniae and Escherichia coli. Bacterial colonization of human blood vessel cells is a hallmark of the PF. Rapid administration of antibiotics effectively treats sepsis, but it has only moderate effect on thrombosis development. The present offer relates to a small molecules family to treat PF. In vitro evaluation of these molecules revealed that they quickly disaggregate bacterial colonies on human endothelial cells, acting on the bacteria type IV pili. The molecules efficacy has been confirmed in vivo using a human skin xenograft in a mouse model, where a drastic reduction of the bacteria colonization of the vascular system is shown. A novel therapeutic strategy can be considered, which would use these molecules to inhibit bacterial virulence without killing the bacteria. The lack of selective pressure should therefore prevent the emerging of resistance towards these small molecules.

Competitive advantages :

  • Novel therapeutic strategy through bacterial virulence inhibition
  • The lack of selective pressure should prevent the emerging of resistance towards the small molecules
  • Can increase efficacy of current antibiotic treatment

Applications :

  • Treating purpura fulminans

Keywords : Purpura fulminans, Neisseria meningitidis, Bacterial adhesion, Type IV pili

PhysiqueMesures & Instrumentation

OPTOMECHANICAL THZ SENSOR

The most advanced commercial technologies for the detection of Terahertz (THz) and far infrared electromagnetic waves have major drawbacks : bolometers work at very low temperatures (4 Kelvin), while Golay cells are notoriously slow (20 Hz). Furthermore, those detectors are bulky, with a typical volume of the device in the 10cm x 10cm x 10cm range. Our MEMS device has a volume in the mm3 range and has a very quick response time (MHz) It works at ambient temperatures. It is possible to tune precisely the resonance frequency of the sensor at production time.

Competitive advantages :

  • Small dimensions (nano to millimeter size)
  • Works at ambient temperatures
  • Very short response time (MHz)
  • Sensivity (equivalent to Golay cells but could be further improved)
  • Easy integration (MEMS technology)

Applications :

  • Spectroscopy for security and nondestructive testing
  • Imaging applications : THz cameras
  • Information carrier conversion from THz wave to an optical fiber

Keywords : THz, Far-infrared, Bolometer, Golay cell, Noise Equivalent Power (NEP)

PhysiqueMesures & Instrumentation

PICOMETER PRECISION SPECTRAL TUNING OF MICRO AND NANOPHOTONIC RESONATORS

State-of-the-art nanofabrication tools (electronic beam lithography, reactive ion etching) can nowadays reach a few nanometer precision. This is still not accurate enough in optical applications such as metrology where collective behavior of resonators is targeted. Our method reaches picometer precision (3 orders of magnitude better than state-of-the-art). The method consists in shedding light on resonators, so that a light-activated chemical etching process can take place. When using the proper wavelength, light intensity is locally amplified by the resonator. The result is that the resonator is gently etched while its nearby environment remains intact. This technique allows as well collective tuning of several resonators for spectral alignment.

Competitive advantages :

  • Requires basic equipment (tunable telecom laser…)
  • Very quick
  • Permanent result
  • Manufacturing of coupled photonic resonators networks with high quality factor
  • Industrial-scalable process (no vacuum nor cryogenic conditions)

Applications :

  • Telecom / datacom : optical routing and multiplexing, semiconductor lasers
  • Optical sensors : gas sensing, optical gyroscopes

Keywords : Nanophotonics, Optical resonators, Silicon photonics, High precision spectral tuning, Photoelectrochemical etching

STICSTIC

Handwritten / printed text discrimination using agent technology (hapedate)

Scanned documents can contain handwritten text, such as annotations, signatures, or filled-in blanks in forms. Identifying those handwritten parts from printed parts is a preliminary step in the treatment chain of the document.
To this end, state-of-the-art approaches are generally using different classifying tools and then compare their results at the end of the classification process. Machine learning algorithms can also be used but in that case, huge databases are usually needed.
Our approach is based on the dialogue of two agents, one assessing the linearity of the writing, the other one the regularity. After an optional learning phase (for example to integrate specific characteristics of a given database), both agents interact to dynamically update their decision models and finally make a common decision, leading to better results than state-of-the-art tools. Without any learning phase, our system reaches an overall recognition rate of 92,3% on the IAM database.
Our system has been developed for Latin alphabets but may be adapted to other alphabets, such as Arabic or Asian writings.

 

Competitive advantages :

  • No need of prior knowledge of the text layout (especially in case of printed forms)
  • No need of databases 
  • No need of deep learning algorithms 
  • Customizable decision function depending on context

 

Applications :

  • Printed text detection and extraction for Optical Character Recognition (OCR)
  • Handwritten text extraction from filled up printed forms
  • Automated detection of manually annotated printed documents

 

Keywords : Agent technology, Optical Character Recognition (OCR), Document analysis

PhysiqueBiologie / SantéMesures & InstrumentationSanté

3D/4D reconstruction of non-adherent cells

While 3D imaging of adherent cells is provided with almost all microscopes, there is currently no reliable and reproducible method for the non-adherent cells. The device presently proposed combines a microfluidic circuit, an electromagnetic field generator and a control software. The combination of these three elements allows studying the cell and its environment in three dimensions while minimizing the exogenous constraints. This solution opens up new fields of basic research in embryology (i.e. monitoring the fusion of gametes), hematology (i.e. liquid cancers) and microbiology.

 Competitive advantages:

  • Standardized method for 3D visualization of non-adherent cells
  • Interoperability with all microscopes
  • Ease of use
  • Improves the resolution of the microscope

 Applications:

  • Hematology
  • Embryology
  • Microbiology
  • Fondamental research

 Keywords: 

Imaging, Biology, Non-adherent cell, 3D, 4D, Microscopy, Hematology, Embryology

Biologie / SantéSanté

HYCO: a novel class of anti-inflammatory compounds

The transcription factor Nrf2 and carbon monoxide (CO) are essential protective systems against oxidative stress and inflammation. The exploitation of these cellular systems may offer new therapeutic avenues in a variety of diseases. The present offer relates to the development of a novel class of antiinflammatory chemical compounds called HYCO, able to activate the Nrf2/HO-1 axis in cells as well as liberate CO. On in vitro models, the addition of these compounds reduces the production of inflammatory markers in different cell lines (macrophages, monocytes, keratinocytes, microglia...). The hit compounds have shown a better anti-inflammatory activity compared to CO-RM and dimethylfumarate (DMF), without cytotoxicity.

Competitive advantages:

  • Novel class of anti-inflammatory chemical entities
  • Novel therapeutic approach with a dual biological activity
  • Better efficacy compared to DMF, CO-RM and their combination


Applications:

  • Treatment of inflammatory diseases, multiple sclerosis, psoriasis
  • Cardiovascular protection
  • Treatment of obesity


Keywords:

Nrf2, CO, Chemical compound, Anti-inflammatory, Cardiovascular, Psoriasis, Multiple Sclerosis

Biologie / SantéSanté

Novel anti-cancer family of chemical agents with anti-proliferative and anti-vascular properties

There is a need for new, efficacious anticancer agents associated with increased response rates and with limited and manageable toxicity.
The present offer proposes a novel chemical compound with antiproliferative and anti-vascular properties validated in vitro and in vivo. This compound has shown high efficient anti-cancer potency in in vitro models using 24 cancer cell lines (some of them being resistant to chemotherapies). In vivo, after intra-peritoneal injection, this compound has shown a tumor volume reduction of 80-95% on lung and colon murine tumors with no major identified side effects. After intra-peritoneal injection, the PK profile in mice is good with a half-life of 91mn and a bioavailability of 47%.

Competitive advantages:

  • New chemical entity
  • Water soluble, stable and easy to synthetize
  • High efficiency in a powerful in vitro colon 26 cell lines
  • Better efficacy than the anti-vascular comparator combretastatin CA4.


Applications:

  • Treatment of solid tumors, in particular in colon, lung, ovaria, uterus


Keywords:

Cancer, Anti-proliferative, Anti-Vascular, Tumor Therapy, Small molecule

Biologie / SantéSanté

Vivinject : nutritive hydrogels enhancing stem cell survival for tissue reconstruction

In the growing market of regenerative medicine, the graft of stem cells is a promising strategy but limited survival of cells post implantation reduces its efficacy. The main role of stem cells in tissue regeneration is to release paracrine factors and therefore stimulate the creation of new vessels, cells recruitment and tissue remodeling. Though to have a significant efficacy, stem cells have to stay alive long enough post-implantation in an ischemic environment.
The research team has demonstrated that mesenchymal stem cells (MSCs) can withstand exposure to severe, continuous hypoxia provided that they have access to glucose ,2. Therefore, they designed a biocompatible material which provides a release of glucose, with good mechanical properties making it easy to handle and injectable. The hydrogel is based on a co-polymer of fibrin and starch containing enzymes capable of producing glucose by consuming starch and therefore, inducing an enhancement of stem cell survival. The enzymes can be encapsulated or not in nanoparticles playing a role of reservoir.
The hydrogel presents interesting mechanical properties, better in vitro and in vivo stem cells survival (tested on three different cell lines), and in vivo cellular colonization. The hydrogel can be conditioned in a doublechamber syringe (injectable form) and has been tested under sterile and different storage conditions.
This technology is providing an environment suitable for stem cell survival even under hypoxic conditions.


 Competitive advantages : 

  • Enhancement of stem cell survival
  • Easy to manufacture
  • Easy handling and storage
  • Injectable

Applications :

  • Hydrogel implant for tissue engineering : i.e. bone graft and cartilage defect
  • Can also be developed for other applications in regenerative medicine

Keywords :

Biomaterial, Hydrogel, Stem cells, Regenerative medicine, Tissue engineering, Bone reconstruction

Biologie / SantéSanté

New non-retractable biomaterial for cell culture

The biomaterial is based on a synthetic interpenetrating polymer network (IPN) of a UV controlled co-reticulated proteic polymer (fibrin based) and synthetic polymer (based on polyethylen glycol) with a fibrin gel obtained in the same medium through an enzymatic reaction. This biomaterial does not shrink over time and allows 2D or 3D cellular colonization making it a perfect in vitro extra-cellular matrix model for cell based assays. This biomaterial can take any wanted shape and size, especially it can be poured at the bottom of culture plate wells without retraction of the gel matrix including High Throughput Screening (HTS) plates. This biomaterial can be easily produced following a “one pot-one shot” process enabling a constant batch to batch quality. In addition it can also be easily handled and stored as it can be lyophilisated and sterilized. This biomaterial is an ideal matrix for cellular growth using different gel thickness on all formats of cell culture plates (even HTS) allowing the development of customized in vitro cell based assays.

Competitive advantages : 

  • Non retractable matrix
  • 2D and 3D matrix for cell culture
  • Easy to produce, handle and store (sterilization and lyophilisation)
  • Compatible with high throughput screening tests

Applications :

  • 2D or 3D matrix for in vitro cell based assays
  • Research or preclinical customized in vitro screening tool

Keywords : Synthetic biomaterial, Copolymer, Fibrin gel, Non-retractable matrix, 2D and 3D cell culture, In vitro cell based assay

 

Biologie / SantéSanté

ENZGEL : a dynamic hydrogel with fine-tuned and controlled release of actives

The present offer relates to the development of new type of gels which are able to successively undergo sol-gel and then gel-sol controlled transitions under the action of two customized antagonistic enzymes, i.e. transglutaminase and protease. These gels are biodegradable after a determined time without any change in temperature or medium composition due to the defined concentrations and ratio between the two enzymes. This unique technology enables to finetuned and controlled release of small and large molecules such as proteins, from 200 Daltons to 2 Million Daltons for its usage in healthcare in particular to deliver anti-biofilm molecules for wound care management. These gels are easy to produce, handle and store. Therefore their applications and potential of usages can also broadly bring solutions in cosmetic and food.

Competitive advantages:

  • Elastic and biodegradable hydrogel
  • Dynamic controlled sol/gel/sol transitions
  • Customized fine-tuned and controlled release of active molecules
  • Anti-biofilm activity
  • Easy to produce, handle and store (sterilization and lyophilization)

Applications:

  • Customized fine-tuned and controlled release of selected active substances
  • Adapted for healthcare
  • Cosmetic and food applications

Keywords : Dynamic elastic biomaterial, Controlled release of active molecules, Healthcare wound care, Cosmetic and food applications

Biologie / SantéSanté

New small molecules to purge HIV reservoirs

Significant progresses have been made in the treatment of HIV infection, in particular in the field of anti-retroviral therapies (ART). However, when ART are stopped or treatment resistance occurs, plasma viral load increases again. This rebound has been attributed to HIV reservoirs in which the pro-virus is in a non-expressing state. The present offer relates to the development of new drugs for the eradication of these HIV reservoir cells using the shock and kill approach. The aim of this approach is to induce expression of viral HIV genes in the latent cells. The cells may then be killed by the damaging effects of virus production (viral cytopathic effect), apoptosis, or may be recognized by the immune system or ART directed towards viral proteins.

Starting from a library screening, the team has optimized 2 hits thanks to the synthesis of 70 analogues and their evaluation in vitro (Structure-Activity Relationship approach). These compounds do not act as HDAC inhibitors and present no cytotoxicity up to 50 µM on a panel of cell lines. Their efficacy has been evaluated ex vivo on primary CD4+ T cells obtained from HIV infected, antiretroviral-treated and aviremic patients and were able to strongly increase the viral load detected.

Competitive advantages:

  • New small molecules
  • Easy to synthetize in 3 or 4 steps without hard conditions
  • Strong reactivation effect in ex vivo studies
  • The compounds do not act as HDAC inhibitors

Applications:

  • HIV treatment in combination with ART

Keywords:   

HIV, infectious disease, reservoir cells, latent infection, shock and kill, small molecules

Biologie / SantéSanté

New mTOR inhibitor for cancer treatment

mTOR (mammalian Target Of Rapamycin) plays a central role in cancer cells. This kinase integrates signals from outside of the cell, including the quantity of available nutrient, and affects energy homeostasis by modulating signaling pathways implicated in proliferation, cell growth and survival. mTOR acts in the form of two protein complexes called mTORC1 and mTORC2. The offer proposes a new inhibitor acting via a novel mode of action on mTOR targeting the two complexes. This chemical compound is active on several cancer cell lines and not cytotoxic on fibroblasts. 

Competitive advantages:

  • Toxic effect on multiple cancer cell lines
  • Not cytotoxic on human fibroblasts
  • Novel binding site on mTOR

Applications:

  • mTOR inhibition for cancer treatment

Keywords: mTOR, mTOR inhibitor, cancer, small molecule, survival pathway

Biologie / SantéSanté

New therapeutic targets for Alzheimer’s disease (AD)

One of the main pathological hallmarks of Alzheimer’s Disease (AD) is the presence of abnormally phosphorylated Tau protein that aggregates to form neurofibrillary tangles (NFTs), which accumulate in affected neurons to finally kill cells. Currently, the abnormal phosphorylation of Tau is considered as the ‘point of no return’ in AD neurodegeneration. Recent findings demonstrate that the glycan-sulfotransferase HS3ST2, responsible for the synthesis of 3-O-sulphated heparan sulphates (3OHS), is overexpressed in AD patients’ brain and that 3OHS are required for the pathological phosphorylation of Tau. In a zebrafish tauopathy model, the inhibition of HS3ST2 markedly reduces Tau abnormal phosphorylation and restores the wild-type phenotype. The present offer relates to the identification of novel potential therapeutic targets for the development of new mechanism-based anti-AD drugs, able to directly and efficiently avoid the abnormal phosphorylation of Tau protein before this occurs.

Competitive advantages:

  • A new mechanism-based target for AD and related tauopathies

Application:

  • Development of anti-AD drugs

Keywords :  Alzheimer’s disease, Tau, Tauopathy, Sulfotransferase

Biologie / SantéSanté

Dual-Color HIV vector to produce, identify and isolate latently infected CD4+ T-cells

Latently infected CD4+ T lymphocytes form the major obstacle to HIV eradication. Elimination of all latent reservoirs is imperative for eradication of the virus from infected individuals. However, the study of HIV latency has been hindered by the relatively low number of latently infected cells within patients and by the lack of relevant in vitro latency cell models.

The present offer relates to the development of a dual color HIV vector allowing the production, identification and isolation of latently infected primary human CD4+ T-cells. The minigenome contains two different fluorescent cassettes: a first marker cassette wherein a HIV LTR promoter controls the expression of a HIV tat coding sequence and the GFP gene; and a second marker cassette wherein the constitutive CMV promoter controls the expression of the mCherry gene. This tool enables the assessment of drug candidates and therapeutic strategies aimed at purging the latent HIV reservoirs and creates a performing in vitro cell model to investigate the molecular mechanisms of HIV latency.

 

Competitive advantage : 

  •  The vector is Biosafety Level-2 compliant and not cytotoxic
  •  The resulting cell model mimics the in vivo HIV reservoirs
  •  The resulting cell subpopulations (infected, latently infected, not infected) are easily sortable by cytometry

Applications :

  • Drug discovery: in vitro screening of drug candidates against HIV reactivation
  • Research: study the molecular mechanisms of HIV-latency

      

Keywords : HIV, dual color vector, Latently infected CD4+ T lymphocytes, HIV reservoirs

Biologie / SantéSanté

PHENOSFISH PLATFORM

Psychoactive molecules are essential tools for treating CNS disorders and exploring nervous system function. However, the lack of accurate in vivo tests has limited the discovery of novel psychoactive drugs over the last decades.

The platform, an automated motility recording system adapted for zebrafish embryos, allows the identification of in vivo novel psychoactive molecules.

It is based on high-intensity light stimulus which elicits a stereotypical series of motor behaviours in zebrafish embryos, the photomotor response (PMR). Interestingly, diverse classes of psychoactive molecules induce distinct, quantifiable and highly reproducible modifications of the PMR. PMR analysis can therefore be used to classify psychoactive drugs according to their activity.

 

Applications : 

  • Pathophysiology and neuroprotection in brain damage
  • Cellular and molecular mechanisms of Central Nervous System (CNS) differentiation
  • Neurodegenerative diseases and therapeutic approaches
  • Zebrafish models of human neurodegenerative diseases (eg. Friedreich’s ataxia, Parkinson’s disease)

Scientific expertise

  • Psychoactive molecules
  • Drugs screening and profiling (classification, toxicity, molecular targets, etc.)
  • Recognized know-how with zebrafish
    Simple protocol with unambiguous output

Keywords : Eco-toxicology, Fetal development, Genetic disorder, Human pathology, Animal model, zebra fish

Biologie / SantéEsprit humain, langage & éducationSTICEducationSanté

BABYLEARN, A TABLET APPLICATION TO TEST COGNITIVE AND VISUOMANUAL COORDINATION ABILITIES OF BABIES

Despite the numerous medical tests and controls young infants have to pass, some troubles are not detected early enough and may later turn into dyspraxia, autism spectrum disorders and visual impairments. It is estimated that about 10% of newborns may be affected by those troubles and the proportion is even higher for preterm newborns. Those troubles may have strong consequences on children development and later lead to school failure and lack of social integration. Moreover, the more the diagnosis is delayed, the less the remediation program is efficient and the more the trouble may remain permanently. Babylearn is a unique application that currently has no equivalent in the market. It only takes a few minutes to run the test and detect subtle dysfunctions to anticipate impairments and handicaps.

Competitive advantages :

  • Precision and accuracy of the test
  • Embedded system solution
  • Quick test (about 6 minutes to run)

Applications :

  • Early trouble detection
  • Can be used in daycare centers, doctors’ offices and hospitals

Keywords : Dyspraxia, Autism spectrum disorders, Visual impairment

Sciences de la terre et de l'universBiologie / SantéAérospatial & DéfenseSanté

GAMMA CAMERA

Gamma cameras have become a mainstream technology for medical imagery. But current PET and SPECT scanners use gamma cameras which mostly have a low sensibility, hence the need of high levels of electromagnetic radiations. Furthermore, 3D images require to use several gamma cameras working by pair, on both sides of the body, so that the price of PET and SPECT scanners can reach several millions of euros. Our solution consists of using a plenoptic camera, which was designed for spatial applications in the first place, and which is currently being adapted for medical imagery. The plenoptic camera uses a coded mask with an efficiency of 10 to 13% versus 0,1% for mainstream gamma cameras (Anger cameras), hence the possibility to reduce by a factor of 100 the dose of the radioactive product injected in the patient. Furthermore, the plenoptic camera uses a microlens array enabling 3D imagery with a single gamma camera, and low cost CMOS electronics to compute the 3D image, leading to downsize the costs of PET and SPECT scanners.

Competitive advantages

  • Efficiency (10-13% vs 0.1% for collimator gamma camera) allowing a 100-fold decrease of the amount of radioactive tracer inoculated to the patient
  • Spatial resolution (1 mm)
  • Limited weight (no collimator)
  • Access to 3D information with a single gamma camera
  • CMOS electronics

Applications

  • Gamma Camera for PET and SPECT scanner
  • Hodoscope (spatial applications)

Keywords : Gamma camera, PET and SPECT scanners, CMOS

STICSTIC

CHOREOGRAPHY SERVICE FOR THE INTERNET OF THINGS

The Internet of Things is composed of heterogeneous objects which often communicate in a master and slave mode with a server or a smartphone, and rarely communicate and interact with other objects. The reason behind is that connected objects are mostly designed for specific purposes within closed industrial ecosystems. Programming choreographies between heterogeneous objects often requires to tackle interoperability issues and limitations of the access to objects’ functionalities.

Our software solution is twofold and consists on one side of a light virtual machine running on the operating system or integrated in the object directly, and on the other side of a server able to establish a secure network between objects, to program and reprogram choreographies from a graphical and intuitive interface and to update objects in real-time.

Competitive advantages :

  • Easy to program / reprogram
  • Compatible with heterogeneous devices and operating systems
  • Protection of data (can work in a local network mode)
  • Energy efficient
  • Bandwidth friendliness
  • Does not require internet access

Applications :

  • Home automation
  • Factories of the future
  • Smart cities
  • Smart health

Keywords : Internet of things (IoT), Virtual machine, Service Choreography, Embedded devices, Energy management

STICLangues, textes, arts & culturesSTICEducationServices financiers & Services aux entreprises

ARABIC LEXICON

In most languages, common nouns, adjectives and verbs can take very various forms in sentences, depending on the grammatical rules of the language. This is especially true in the Arabic language, where a single root of three consonants can generate hundreds of different forms. While traditional dictionaries cover only a small fraction of the whole range of forms found in texts, our technology has been used to generated a database of 65 000 entries with their 6 millions of forms, covering more than 98 % of the forms found in any sort of text (literature, newspaper articles etc.), the remaining 2% including proper names. Arabic Lexicon interfaces with Unitex, which is an open source corpus processing system for language processing, developed by Gaspard Monge Laboratory (LIGM UPEM). Unitex Arabic has been presented to prestigious organizations, like Al-Ghazali Institute of La Grande Mosquée de Paris and L’Institut du Monde Arabe. It now can be used in a wide range of domains, like text editors, digitalization of printed documents, data mining in Arabic web contents and e-learning of Arabic.

Competitive advantages :

  • Accuracy
  • Exhaustivity
  • Responsiveness

Applications :

  • Orthographic correction
  • Automatic typing word completion
  • E-reputation analysis on web sites
  • E-learning of the Arabic language
  • Digitalization of documents

Keywords : Semitic languages, Arabic, Orthography, Grammar, Unitex

Biologie / SantéMesures & InstrumentationSanté

MICRO ELECTRODE ARRAY

Probes used for stimulating living tissues or for recording living tissues’ answer to stimulation are usually composed of a micro electrode array (MEA) wire bonded to a print circuit board and to a connector. The MEA generally has the form of a fork whose silicon teeth are very fragile. The whole probe is expensive and has to be replaced in its entirety when the MEA is damaged. The development of new probes in which the MEA is demountable enables to limit the consumable part that has to be changed when the probe is defective. The replacement costs are thus far reduced. This new design also leads to a more versatile device as the “MEA fork” can be adjusted according to the desired application or to the tests to be done. Furthermore the electronic part which is usually delocalized can now be placed close to the PCB which is no more disposable, leading to an increased signal to noise ratio (SNR). This new MEA device is one step further towards hybrid systems connecting artificial and biological neural networks, for example devices able to restore an organ functional activity after a nerve lesion.

Competitive advantages :

  • Modularity
  • Reduced replacement costs
  • Versatility
  • Improved SNR

Applications :

  • Stimulation of living tissues
  • Recording of living tissues’ answer to stimulation

Keywords : Micro Electrode Array (MEA), Optogenetics, Neurophotonics, Microfluidic, Hybrid Neural Networks for rehabilitation

PhysiqueChimieSciences pour l'ingénieurChimie, Matériaux & Produits alimentaires

THERMOMECHANICAL PLATFORM

Most of the formulated products are obtained by an optimal mixing of several components. Flow properties for fluids or viscoelastic properties for pasty materials are then essential for their final conditions of use (e.g. applying a paint on a solid surface or a cosmetic product on the skin under shear) or for the development of stimulated materials by change of pH, temperature, electrical or magnetic field, UV radiation, etc. These properties are connected to physicochemical properties of raw materials and final products. It is therefore essential for producers to have good knowledge of these physicochemical properties in order to achieve the best formulation and process of production. This platform is an experimental and comprehensive tool to help in the formulation of structured materials and the study of their thermomechanical properties. The platform is composed of a set of controlled strain or torque rheometers with different geometries (double cylinders, cone/plate, plate/plate), texture analyzers, nanosized and charged particles surface potential measuring devices, optical microscopes, a differential scanning micro-calorimeter, an UV visible spectrometer and a fluorescence spectrometer. It allows flow measurements, viscoelasticity measurements, compression and expansion analysis, isothermal calorimetry analysis or dynamic scanning calorimetry, microscopic observations and optical density measurements.

Offer :

  • Material testing services : formulation/deformulation studies, thermomechanical analysis, dynamic and structural property evaluations, flow measurements and viscoelasticity measurements
  • Product development services : idea generation, composite material testing, performance evaluation, production improvements
  • Customized synthesis services : production process evaluation/optimization, raw material quality analysis, new formulation seeking
  • Training : continuous training seminars, intracorporate training, tailor-made training, consulting service

Scientific expertise :

  • Physicochemical formulation
  • Nano/Micro structured materials, composite materials
  • Liquids, pasties, gelled structures
  • Critical analysis of raw data linked to final applications
  • Choice of optimal experimental tools, development of best fitted experimental protocols

Keywords : Rheology, Thermomechanical analysis, Formulation, Deformulation, Viscoelasticity measurement, Flow measurement, Nanomaterials

ChimieEcologie / EnvironnementChimie, Matériaux & Produits alimentaires

VALORIZATION OF CO2 VIA A NEW KIND OF CATALYSTS

CO2 is a highly stable molecule that needs a lot of energy in order to be transformed and react with other molecules. Hence, CO2 utilization by the industry has remained limited. However, one could see CO2 as a source of carbon and use this material to store energy by breaking C-O bonds and making energy-rich C-H bonds instead. Over the past 20 years, thousands of scientific articles about CO2 catalyzed reduction have been published but the reported catalysts are either based on rare materials (such as Pd, Re, Ru) or show poor performances. In contrast, our PEM technology based on iron porphyrin catalysts is very promising since it does not rely on rare materials and has proved excellent performances to turn CO2 into CO at ambient temperatures both in organic and neutral pH aqueous solutions. Electrogenerated CO could be further processed with green hydrogen for synthetic fuel production.

Competitive advantages :

  • Cheap catalyst (Fe) vs. actual ones (Ru, Rh, Pd, Re, Pt…)
  • Ambient temperature / Atmospheric pressure
  • Compatible with organic and aqueous solvents (pH 7)
  • High catalytic efficiency (>90% selectivity, low overpotential)
  • Heterogeneous catalysis
  • Catalytic film materials do not require any special care

Applications :

  • Chemical industry: synthesis of CO and syngas used for the production of methanol or synthetic fuels
  • CO2 capture and utilization (CCU)
  • Valorization of intermittent sources of electricity (energy conversion and storage)

Keywords : CO2 valorization, CO2 electroreduction, Low cost catalyst, Iron porphyrin, Carbon monoxide, Synthetic fuels, Syngas, Electrofuels, Energy conversion and storage

Sciences de la terre et de l'universMesures & Instrumentation

CORRECTION METHOD OF ISOTOPE RATIO MEASUREMENTS

Measuring isotope ratios is a very powerful technique to determine the characteristics and the history of a sample of matter. For example, measuring the ratio of two carbon isotopes (Carbon-14 and Carbon-12) within a fossil determines its geological age. Plenty of other applications can be found, such as in nuclear industry, environment monitoring, cosmetic industry and even forgery detection in art paintings. Multiple collector - inductively coupled plasma - mass spectrometry (MC-ICPMS) is a best-in-class equipment to determine such isotope ratios as it works with a wide range of chemical elements and has very low detection thresholds. Samples of matters need to be prepared before being fed to the MC-ICPMS, either through a hyphenation technique (GC, HPLC, electrophoresis, …) or a particular sample introduction (flow injection, laser ablation, …). The problem is that this preparation step introduces an isotope ratio drift due to a time lag (Δt in the picture) between the measurements of the different isotopes, making results difficult to interpret. Our mathematical model calculates and compensates the time lag due to the collector-amplifier system imperfections. Classical techniques to determine the isotopic ratio (point by point method or linear regression method) can then be used. The intern incertitude and the trueness are highly improved. This efficient correction method does not need any intervention on the instrument (calibration…) and can easily be integrated as an add-on to the MC-ICPMS software for data treatment.

Competitive advantages :

  • Software solution to compensate hardware imperfections
  • No calibration or any intervention on the instrument is needed
  • Trueness and intern incertitude highly improved

Application :

  • Data processing of isotope ratio measures in mass spectrometers

Keywords : Isotope ratio, Mass spectrometer, MC-ICPMS

Sciences pour l'ingénieurSTICSTIC

OPTICAL FIBER COUPLING STRUCTURE

Connecting a light source or a receiver to an optical fiber requires to align precisely the formers to the latter. This is currently done with what is called an active coupling method, consisting in turning on the laser, using a ball lens and slowly aligning the fiber with the laser or the photodetector. Our technology consists in placing a passive structure between the optical fiber and the laser or the photodiode. This method takes only seconds to carry out as it does not require turning on the optical source. Thanks to an optimized geometry, the passive structure has a good tolerance to misalignment and reaches a 60%-80% coupling efficiency with a 10-micrometer misalignment (where traditional methods have a steep decrease in coupling efficiency, reaching 50% with a 1micrometer misalignment). The invention allows to realize a collective substrate with collective coupling truncated elements between the optical fiber and the laser or the photodiode, the coupling elements having some forms tuned by the method of the invention.

Competitive advantages :

  • 60-80% coupling efficiency with a large alignment tolerance (10 microns vs 2 microns with a ball lens)
  • Cost effective production with passive alignment
  • Wafer scale production
  • Potentially adaptable to multimode and single-mode fibers
  • High coupling efficiency with high speed photodetector (9 microns diameter)
  • Production potentially done on the same wafer as emitter/receiver

Applications

  • VCSEL to fiber coupling
  • Photodetector to fiber coupling

Keywords : VCSEL, Monomode fiber, Multimode fiber, Photodetector, Coupling efficiency, Photonics, Optoelectronics

STICSTICSanté

FAST IMAGE QUALITY ASSESSMENT

Blur can be detected by comparing different images of a same subject (auto-focus) or by an absolute quantification (Fourier transform or wavelet transform). The first algorithms are faster (0.4s/Mpixel) but do not provide accurate blur quantification. The second algorithms do not need comparison with several images but are slower (>2s/Mpixel) and therefore not adapted to the analysis of large images such as virtual slides of biological tissue or large data bases such as document archiving. The proposed algorithm provides a score indicating the level of blur in an image or in a part of an image. It presents a very low complexity thanks to the simple scoring method developed and can achieve a very fast blur quantification (0.02s/Mpixel) adapted to large images.

Competitive advantages :

  • Fast blur quantification (0.02s/Mp vs 0.4s/Mp with standard techniques)
  • Absolute quantification from a unique image
  • Global or local blur quantification

Applications

  • Blur quantification in very high resolution images, such as histology virtual slides
  • Blur quantification in very large image data bases, such as scanned document archiving

Keywords : Blur, Image Quality, Radiology, Anathomopathology, Histology, Virtual slides

Biologie / SantéMesures & InstrumentationSanté

MEASUREMENT OF COLONIC TRANSIT TIME

To evaluate the origin of digestive disorders, such as constipation, diarrhea or irritable bowel syndrome, the quantification of the food transit through the digestive system is generally needed. In standard procedure measuring this colonic transit time is realized by ingesting radiopaque markers during several days and observing their distribution by X-ray. The use of a X-ray radiography is costly and time consuming for both hospitals and patients, in case of strong constipation or diarrheas protocols cannot be customized as X-ray exposition needs to be minimized, and abdominal radiographs are not adapted to pregnant women and children. The present offer proposes a technology solving these problems by replacing the radiopaque markers by RFID tags. These tags can be localized with a portable and inexpensive equipment and a simple computer directly in the examination room.

Competitive advantages :

  • No X-ray scanner is required
  • Protocols can be customized to strong constipations and diarrheas as the technology allows more frequent measurements
  • Protocols can be adapted to pregnant women and children
  • Possibility to identify individual markers

Applications :

  • Gastroenterology : measurement of colonic transit time

Keywords : Radiography, Gastroenterology, UHF RFID, Colonic transit time

Biologie / SantéSanté

NEW THERAPEUTIC APPROACH AGAINST SPINAL MUSCULAR ATROPHY (SMA)

Spinal muscular atrophy (SMA) is a neurodegenerative disorder leading to progressive muscle weakness, atrophy, and in severe types, premature death. It is classified as a rare disease affecting 1 in 6000 births. SMA is caused by the mutation or deletion of the survival motor neuron-1 (SMN1) gene, which encodes the SMN protein, necessary for the survival of motoneurons. Several drug candidates aim at motoneuron protection or SMN protein levels increase. However, until now, no treatment is available against SMA.

It has been shown that SMN localizes in Cajal Bodies and that the localization is affected in SMA patients. The present offer relates to a new therapeutic approach based on relocation of SMN into Cajal Bodies to restore its function and improve the SMA phenotype. Through an in vitro screening on SMA patients’ cells, Flunarizine has been identified as a hit candidate to relocate and restore SMN function. In vivo studies in a mouse model show relocation of SMN into Cajal Bodies as well as a strong improvement of survival and mobility. More recent studies show effects on both muscles and neurons (results available under NDA) and ongoing research will elucidate the details of the mechanism of action.  

Competitive advantages :

  • New therapeutic approach based on relocation of SMN protein
  • Well known compound (Flunarizine) as hit candidate

Applications :

  •  Therapy against SMA
  •  Possible combination with therapeutics aiming at increasing SMN levels

Keywords : Spinal Muscular Atrophy, SMA, SMN, Relocation, Flunarizine, Rare disease

Biologie / SantéSanté

NEW FORMULATION OF LIDOCAINE WITH RAPID ONSET OF ACTION

Topical anesthetics, creams or patches, provide a local anesthesia before a superficial operation by penetrating the epidermis to target directly free nerves endings in the dermis. Lidocaine is the most widely used topical anesthetic and most commonly used creams are formulated from an eutectic mixture of lidocaine and prilocaine. However, prilocaine has been associated with increased risk of side effect (methemoglobinemia), especially in pediatry. The present offer proposes an optimized anesthetic emulsion free of prilocaine, formulated from a eutectic mixture of lidocaine and unsaturated fatty acid (UFA). Nanoemulsion and richness in UFA give our product the advantage of a quick transdermal delivery of drugs. Furthermore, the formulation at a physiological pH avoids skin irritation observed with available topical anesthetics.

Competitive advantages :

  • Formulation free of prilocaine
  • Potential for long duration and fast onset of action compared to LMX and EMLA
  • Expected to reduce skin irritation
  • Compounds of proven safety
  • Nanoemulsion stable between 6° and 35°
  • Auto-emulsifiable system facilitating the production process
  • pH neutral (EMLA basic)
  • Several formulations possible : gel, spray, cream, patch, etc

Applications :

  • Topical anesthesic (cream, spray, patch,..) or anthalgic formulation free of prilocaine
  • Topical cream or gel for premature ejaculation

Keywords : Lidocaine, Fatty acid, Topical anesthetic or anthalgic, Premature ejaculation, Eutectic mixture

Biologie / SantéSanté

DRUG DISCOVERY TOOL FOR NEURODEGENERATIVE DISEASES

Using patient-specific neuronal cells is a promising approach for the diagnosis and treatment of neurodegenerative diseases and for scientific research. However, current methods to produce or extract neuronal cells are highly invasive or drastically alter the cell genome. The present offer proposes a new method, alternative to iPS, for differentiating white blood cells, extracted from fresh human blood, into neuronal-like cells without cell reprogramming. The resulting
cells structurally resemble neurons, present spontaneous electrical activity and express a wide variety of neuronal markers. A 40% differentiation-rate, within 3 weeks, was reached following a simple and robust protocol (developed at Cochin Institute and Sainte-Anne Hospital). This method can be used to generate in vitro models of neuropathologies for drug discovery.

Competitive advantages :

  • Robust method to obtain neuronal-like cells within a short timeframe
  • Easily accessible cells (blood sample) for transdifferentiation
  • Electrical activity of cells obtained
  • No alteration of cell genome

Applications

  • Broad medical research tool (neurodegenerative disease modelling)
  • Identification of biomarker w/o genetic alteration
  • Useful for developing drug screening test adapted to patient (personalized medicine)

Keywords : Neuronal-like cells, Transdifferentiation, Neurodegenerative diseases, Research tool

Biologie / SantéSanté

DIAGNOSTIC KIT FOR ACUTE GVHD PREDICTION

Acute graft versus host disease (GvHD) is the main source of morbidity and mortality for patients after allogenic hematopoietic stem cell transplantation. It is caused by the reaction of some immune cells contained in the grafted hematopoietic stem cells against the host. Up to now, despite the use of donor selection criteria (HLA histocompatibility, sex, age and medical history), there is no efficient way to predict acute GvHD. It was recently found that the amplification capacity of a rare T lymphocyte subpopulation in the graft was correlated to the occurrence and severity of GvHD. The present offer proposes a kit for the prediction of grade II to IV acute GvHD based on the culture of these immune cells. Their amplification predicts a reduced risk of GvHD while an absence of cell amplification reflects an enhanced risk of severe GvHD.

Competitive advantages :

  • First accurate GvHD prediction method before graft
  • First kit based on T lymphocyte culture
  • Simple and robust in vitro diagnostic method (processing in hospital labs)

Applications

  • Detection kit to prevent acute GvHD in case of hematopoietic stem cell transplantation
  • Potential enlargement to other organ transplantations

Keywords : GvHD, T Lymphocyte, Diagnostic kit, Prediction kit, Transplantation, Cell culture, HSCT

Biologie / SantéSanté

NEW POTENT BLOCKER OF HER2 RECEPTOR FOR TREATMENT OF METASTATIC BREAST CANCER

20 to 30% of breast cancers are related to an overexpression of HER2 and among them, 20 to 40% express p95HER2, a truncated version of the receptor believed to play a role in cancer resistance. Despite the benefits of the recent therapies targeting HER2 (Herceptin®, Perjeta® and Tykerb®), a large part of patients relapses because of treatment failure due to cancer resistance or toxicity issues. Notably, 20% to 50% of HER2 metastatic breast cancer patients die of brain metastases.

It was recently found that targeting a new domain of HER2 prevents the activation of HER2 signalization and may constitute a novel therapeutic approach. The present offer proposes two compound families targeting this domain and inhibiting specifically HER2 downstream signaling pathways in breast cancer. The compounds are able to cross the blood-brain barrier and, therefore, to target brain metastases.

Competitive advantages :

  • New intracellular target domain on HER2 protein

  •  Effective on HER2 wild type as well as known drug resistant mutants such as p95HER2

  • Small molecules crossing the Blood-Brain Barrier to target brain metastases

Applications

  • Treatment of breast cancer’s brain metastases

  • Treatment against HER2+ breast cancers resistance

  • Potential treatment of other HER2+ cancers (ovarian, gastric, salivary, neuroblastoma etc)

Keywords : HER2, Breast Cancer, Targeted Therapy, Small Molecule, Brain Metastasis

Biologie / SantéSanté

CHLAMYDIA VACCINE

With more than 100 million cases every year, Chlamydia infection continues to be the most commonly reported sexually transmitted bacterial infection in many countries, especially for women. Current treatments with antibiotics are not completely effective against chlamydia infection and there is no available vaccine in the market at this stage. Chlamydia infection is also a problem among pets or livestock animals. Indeed, a large range of animals can be infected with some
Chlamydia strains and there is no prophylactic immunization that gives a 100% protection. The present offer proposes a vaccine candidate for the prevention
of chlamydia infections. The vaccine candidate involves killed form of Chlamydia with presence of native antigens. Mice infected with Chlamydia muridarum after vaccination present no lesion in genital organs compared to control mice (with no vaccination).

Competitive advantages

  • Killed form vaccine
  • Highly immunogenic form
  • Prevent chlamydia-induced lesions

Applications

  • Chlamydia infection prevention in humans
  • Veterinary Market : All Chlamydiaceae (Chlamydia & Chlamydophila) infections in different species

Keywords : Chlamydia, Vaccine, Killed bacteria

Biologie / SantéSanté

CRYOOGEL – NEW CRYOPRESERVATION MATRIX

The long-term cryopreservation of cells and tissues is a crucial challenge, in particular for reproduction and cell therapy, but the current cryopreservation additives are not totally safe and efficient. The challenge of cryopreserving cells is their limited resistance to freezing and thawing. In particular, the formation of ice both inside and outside the cells will alter both their cellular structures and their biochemical equilibrium. Cryopreservation agents have been developed to reduce the formation of ice during freezing. However, most of these agents have shown toxicity at high concentrations and moderate efficacy depending on the applications. The present offer proposes an optimized biocompatible polysaccharide hydrogel adaptable to numerous cryopreservation applications and techniques. Its raw materials are already validated for pharmaceutical use. Preliminary data shows an absence of toxicity and the efficacy for cryopreservation of oocytes, embryos, endothelial cells, tissues, hematopoietic progenitors with slow freezing. Recently, the physicochemical properties of the hydrogel have been defined as well as the most appropriate compositions and granularities in function of cells and cryopreservation techniques. In vitro experiments are ongoing on oocytes, cord blood hematopoietic progenitors and other sensitive cells to demonstrate the viability and functionality of the cryopreserved cells. This new product, CryoOgel, will reduce or even eliminate the need for the current toxic agents and proposes a new way to handle cryopreservation.

Competitive advantages

  • Biocompatible
  • Applicable to gametes, stem cells, sensitive cells and tissues
  • Do not penetrate the cells
  • Applicable for both slow freezing and vitrification
  • Easy separation from cells by dispersion
  • Made from pharmaceutical grade compound

Applications

  • Reproduction (medical and veterinary)
  • Cell therapy
  • Biobanking
  • Research tool (rare and sensitive cells)

Keywords : Cryopreservation, Hydrogel, Biobanking, Slow-freezing, Vitrification, Additive, Cryopreservative agents, Oocytes, Sperm, Sensitive cells, Cord blood stem cells

Biologie / SantéSanté

NEW STRATEGY FOR TARGETING CANCER STEM-LIKE CELLS

Increasing evidence suggests that the systematic relapse and cancer metastasis of most solid tumors such as glioblastoma, is due to a rare population of cells within the tumor, termed cancer stem-like cells (CSCs). These cells have stem-like traits such as self-renewal capacities, are resistant to conventional chemotherapies and radiotherapies and thus operate as a niche-specific signal that sustains tumor initiation and progression. A signaling pathway that
is specific to CSCs and responsible for their identity, survival and selfrenewal has been recently characterized in glioblastoma. While today no treatment specifically targets cancer-stem-like cells, the present offer proposes a new hit molecule inhibiting a cell surface receptor of this pathway in these cells to reduce / eliminate their activity with a high efficiency both ex vivo and in vivo.

Competitive advantages :

  • First efficient treatment targeting cancer stem-like cells which are implicated in tumor initiation and therapeutic resistance
  • Strong tropism for CSCs
  • Mechanism of action identified
  • The cell surface target is possibly also involved in other lifethreatening cancers

Applications

  • Glioblastoma treatment targeting tumor initiation, progression, resistance and recurrence
  • Potential treatment for other solid tumors

Keywords : Glioblastoma, Cancer Stem-like Cells, CSCs, Cancer Recurrence, Peptide

Biologie / SantéSanté

NEW CELL THERAPY FOR ACUTE GVHD

Acute graft versus host disease (GvHD) is the main source of morbidity and mortality for patients after allogeneic hematopoietic stem cell transplantation (HSCT, 20 to 90% in severe cases) and has currently no specific and effective treatment. This disease is caused by the reaction of conventional T cells contained in the grafted hematopoietic stem cells against host. Allogenic Tregs have been used in several recent clinical trials to prevent GvHD but their efficiency is limited.
Exo Tregs developed by this offer are specific to an irrelevant antigen (not present in host or donor) and can be activated after transplantation at a chosen time by administration of the irrelevant peptide to the transplanted patient. With this inducible system, conventional T cells can elicit their anti-tumor effect before being suppressed by antigenactivated Tregs which prevent GvHD, thus optimizing the anti-tumor therapy and improving HSCTs outcomes.

Competitive advantages :

  • 1st safe antigen-specific Tregs
  • Good balance of anti-tumor vs GvHD
  • Better efficiency than Allo Tregs
  • No global immunosuppression
  • Inducible system allowing Graft-versus-Tumor effect optimizatio
  • GMP-compliant Treg isolation procedure

Applications

  • Prevention of acute GvHD
  • Treatment of acute GvHD
  • Allogenic Hematopoietic Stem Cell Transplantatio
  • Other diseases caused by pathological T cells (autoimmune diseases, organ transplant rejection)

Keywords : Exo Tregs, GvHD, HSCT, Cell Therapy, Immunosuppression

STICSTIC

SurfOnMedia

SurfOnMedia is a unique demodulation architecture and method to demodulate simultaneously multiple radio signals, such as TV and radio. The solution does not require one demodulation circuit for each band and uses instead a unique circuit. The system can also reemit one or more radio signals on another band of frequencies. The modulation techniques and communication protocols can be configured by the user and reprogrammed at any time. It therefore improves the overall receiver cost, energy consumption and flexibility.

It could be an efficient solution for monitoring broadcast networks, and also to broadcast several channels in a building, car or train, or record all TV and radio channels simultaneously. It could be adapted for white spaces or Licensed Shared Access (LSA) applications.

Competitive advantages :

  • Simultaneous access to all channels
  • Multi-standard receiver
  • Software Defined Radio (SDR)

Applications

  • Broadcast monitoring
  • Radio and TV receivers for car, trains or planes
  • Radio and TV catch-up for homebox
  • White spaces or LSA

Keywords : Demodulation, Multi-channels, Software Defined Radios, Resources cost optimization, FM, DVB, DRM, DAB, DMB, LSA, White Spaces

Biologie / SantéEsprit humain, langage & éducationEducationSanté

RAPDYS (ALLOPHONIC REMEDIATION OF DYSLEXIA)

RapDys is a phonological training program for dyslexic children, which has been clinically trialed

Dyslexia is a specific learning disability that affects about 7% of the population and in particular 200 000 children between ages 6 and 11 in France. Children with specific language impairment (SLI) have difficulties in several aspects of language, including phonology, morphology and syntax, despite normal intelligence, adequate hearing, normal learning opportunities and the absence of any neurological or psychiatric trouble. RapDys are gamelike exercises based on carefully chosen and tested voicing continua. They can be done under the supervision of a speech and language therapist and further on at home. After only nine training sessions of 20 minutes each, children suffering from SLI have increased up to 40% their performance in the identification, discrimination and categorical perception. Children have been tested again one month after the last training, and performance levels have shown to remain stable.

Competitive advantages

  • Technology proved during clinical trial
  • Available on any device (PC, smartphone, tablet)
  • Quick exercises (couple of minutes)
  • Gamelike

Applications :

  • Specific language impairment treatment
  • Speech therapy

Keywords : Dyslexia, Specific language impairment (SLI), Phonology, Voicing continuum

PhysiqueSciences pour l'ingénieurSTICEnergie & Systèmes électriquesSTIC

MEMS for vibration energy harvesting

Microsystem for harvesting vibration energy at low mechanical frequencies

For embedded systems, battery liftetime is often a critical issue and finding ways to increase it could provide major benefits. For example, improving the battery lifetime of pacemakers would postpone the chirurgical operation needed to replace the battery, while for smart clothes, tackling the battery issue would open a wide range of new applications.
When the embedded system is a wearable one, it is possible to harvest the mechanical energy due to human movements and convert it into electrical energy. But mechanical energy harvesters work efficiently only at a given mechanical frequency which is linked to their size. So when it comes to designing a miniature energy harvester, the mechanical frequency generally exceeds 100 Hz, far beyond the spread of human movements.
Our MEMS electrostatic harvester has an internal structure designed to provide electrical power efficiently at low and wideband frequencies, making it suitable for wearable devices.

Competitive advantages :

  • Microsized system (actual prototype is 10 mm x10 mm x3 mm)
  • Versatile solution for harvesting energy from human movements (Hz or tens of Hz) to higher frequencies (hundreds of Hz)
  • Important power density for a microsystem operating at low frequency (10 microW/cm3 at 10 Hz in most recent prototypes, conversion efficiency ~60%)

 

Keywords : Vibration energy Harvesting, MEMS, Low frequency operation, Electrostatic transducer